Epstein-Barr Virus LMP1-Mediated Oncogenicity.

نویسندگان

  • Liang Wei Wang
  • Sizun Jiang
  • Benjamin E Gewurz
چکیده

Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches.

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عنوان ژورنال:
  • Journal of virology

دوره 91 21  شماره 

صفحات  -

تاریخ انتشار 2017